Portion of a proximal convoluted tubule from a rat kidney with experimental hemoglobinuria. A mass of dense hemoglobin completely fills the tubule lumen and outlines the microvilli of the brush border...

Portion of a proximal convoluted tubule from a rat kidney with experimental hemoglobinuria. A mass of dense hemoglobin completely fills the tubule lumen and outlines the microvilli (MV) of the brush b...

Cultured retinal pigment epithelial cells immunofluorescently labeled for adaptor protein-2 (AP2) (green) and nucleus (blue). The cells were fixed in 2% PFA and 0.5% Triton X-100 for 2 minutes follow...

A clump of at least seven small clathrin cages that are probably connected to an early endosome (below the fracture plane). The morphology of these cages shows a tighter packing than the larger clathr...

A high resolution of a quick-freeze deep-etch rotary shadowed replica of a parasomal sac from which a clathrin-coated preendosomal vesicle has pinched off. The typical clathrin cage structure is prese...

Higher resolution of the area that shows the clathrin-coated cage near the peniculus and clathrin coated preendosomal and partially coated preendosomal vesicles. Early endosomes like the preendosomal ...

Higher resolution image of the area that shows the clathrin-coated cage near the peniculus and clathrin coated preendosomal and partially coated preendosomal vesicles. Early endosomes like the preendo...

High resolution image of quick-freeze deep-etch rotary-shadowed replica of an early endosome with two clathrin-coated evaginations. Presumably these coated pits contain receptors for cargo that will b...

High resolution image of a cell sectioned perpendicular to the surface. The parasomal sac ends internally as a coated pit, coated with clathrin. Where the coated pit has pinched off a clathrin-coated ...

High resolution micrograph following trifluoperizine (TFP) treatment, which apparently does not inhibit endocytosis but does inhibit movement of vesicles away from the parasomal sacs, coated and preen...